In Vitro Anticancer and Antioxidant Potential of Pittosporum dasycaulon Leaves extract Against the Human Liver and Lymphoma Cancer

Cancers are the uncontrolled growth of cells or tumors, and it is one leading causes death all over world. Currently, available synthetic drugs such as cisplatin, doxorubicin fluorouracil reported to have notable side effects in living tissues (skin irritations, dry cracked skin, mouth sores). So researchers scrutinizing for alternative medications overcome these effects. Plants vital sources medicines with less toxicity may side-effects drugs. The study evaluated cytotoxicity antioxidant potential on methanolic aqueous extract Pittosporum dasycaulon leaves. In present cytotoxicity, selected extracts were screened against two cancer cell lines (human liver Lymph cell-Dalton's lymphoma ascites ascites). Two normal cells, intestinal epithelial-6, Rat spleen used test by using trypan blue exclusion method 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide assay. antiradical activity was also its half maximal inhibitory concentration. content total phenolic, flavonoid saponins estimated. displayed leaves found a significant rate (Dalton's human cells) lethal concentration 50 values ranging from 8.21±0.3 55.65±0.11 μg/ml. However, same had very even higher doses non- cancerous (intestinal epithelial-6) rat 389.50±0.6 1800.00±0.1 quantitative analysis leaf showed high level phenolic compounds. Therefore, Miq promising candidate natural well anticancer components. Hence, further extensive urges evaluate mechanism investigate individual components responsible potential.